Hepatitis B Virology for Clinicians
نویسندگان
چکیده
منابع مشابه
[Molecular virology of the hepatitis B virus].
The hepatitis B virus (HBV) belongs to the hepadnavirus family. The genome of the virus, formed by a small DNA molecule with 3,200 base pairs, has 4 strongly overlapping protein coding regions: ORF preS/S, corresponding to the envelope proteins that constitute the HBV surface antigen (HBsAg); ORF preC/C, which encodes the viral capsid component (core antigen or HBcAg) and a non-structural prote...
متن کاملHepatitis B virus: molecular virology and common mutants.
A high rate of viral turnover, combined with an error-prone polymerase, results in a very high frequency of mutational events during hepatitis B virus replication. Mutants may accumulate, particularly in individuals at advanced stages of persistent infection and with antibody- and cell-mediated immune responses to the virus. Specific mutants may be selected from these populations, especially by...
متن کامل[Virology, epidemiology and transmission mechanisms of hepatitis B virus].
Illness due to the hepatitis B virus is an enormous problem for international public health, affecting over 300 million persons throughout the world, although its prevalence varies considerably between different geographic areas. The universal vaccination of the newly born, promulgated by the World Health Organisation, has made it possible to partially control the spread of the virus in many co...
متن کاملA Multistage Group Education for Hepatitis B
Abstract Introduction. Hepatitis B is the most common cause of end stage liver disease in Iran. As a high-cost disease with a relatively high incidence, and the relative lack of community knowledge, it warrants initiation of a public health intervention in Iran. Methods. This was a Before-After educational intervention that analyzed the data obtained from questionnaires filled out by 80 pat...
متن کاملMolecular virology of hepatitis B virus and targets for antiviral intervention.
The members of the viral family Hepadnaviridae comprise one of the smallest enveloped DNA viruses and cause acute and chronic infections in mammals and birds, leading to large virus and antigen loads in the blood. They have a restricted host range and depend on differentiated hepatocytes for replication. Hepatitis B virus (HBV) is the prototype of the Hepadnaviridae. HBV can persist in infected...
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ژورنال
عنوان ژورنال: Clinics in Liver Disease
سال: 2010
ISSN: 1089-3261
DOI: 10.1016/j.cld.2010.05.001